The Ca2+-sensing receptor (CaSR) belongs to the class III G-protein-coupled receptors (GPCRs), which include receptors for pheromones, amino acids, sweeteners, and the …
Combinatorial chemistry and library design have been reconciled by applying simple medicinal chemistry concepts to virtual library design.
Racemic 2-O-[4‘(9‘ ‘-N-purinyl)butyl] myo-inositol 1,4,5-tris(phosphate) 8 was synthesized starting from myo-inositol.
N,N‘-Linked oligoureas with proteinogenic side chains are peptide backbone mimetics belonging to the γ-peptide lineage.
In mammals, the vasopressin V(1b) receptor (V(1b)-R) is known to regulate ACTH secretion and, more recently, stress and anxiety.
Neprilysin 2 (NEP2), a recently identified member of the M13 subfamily of metalloproteases, shares the highest degree of homology with the prototypical member of the family …
Mutations of the developmental gene Sonic hedgehog (SHH) and alterations of SHH signaling have been associated with holoprosencephaly (HPE), a rare disorder characterized by a …
The current study describes the development of a computer package (GPCRmod) aimed at the high-throughput modeling of the therapeutically important family of human G-protein coupled …
A three-dimensional model of the human extracellular Ca2+-sensing receptor (CaSR) has been used to identify specific residues implicated in the recognition of two negative …
The Protein Data Bank (PDB) has been processed to extract a screening protein library (sc-PDB) of 2148 entries.