Bissantz, C. | Chemogenomics Structural Group

High-Throughput Modeling of Human G-Protein Coupled Receptors: Amino Acid Sequence Alignment, Three-Dimensional Model Building, and Receptor Library Screening

The current study describes the development of a computer package (GPCRmod) aimed at the high-throughput modeling of the therapeutically important family of human G-protein coupled …

Bissantz, C.

• May 1, 2004 • 1 min read

GPCRs

Protein-based virtual screening of chemical databases. II. Are homology models of g-protein coupled receptors suitable targets?

The aim of the current study is to investigate whether homology models of G-Protein-Coupled Receptors (GPCRs) that are based on bovine rhodopsin are reliable enough to be used for …

Bissantz, C.

• Jan 1, 2003 • 1 min read

Animals

Probing the cysteine-34 position of endogenous serum albumin with thiol-binding doxorubicin derivatives. Improved efficacy of an acid-sensitive doxorubicin derivative with specific albumin-binding properties compared to that of the parent compound.

We have recently proposed a macromolecular prodrug strategy for improved cancer chemotherapy based on two features (Kratz, F.

Kratz, F.

• Dec 1, 2002 • 1 min read

Protein-Based Virtual Screening of Chemical Databases. 1. Evaluation of Different Docking/Scoring Combinations

Three different database docking programs (Dock, FlexX, Gold) have been used in combination with seven scoring functions (Chemscore, Dock, FlexX, Fresno, Gold, Pmf, Score) to …

Bissantz, C.

• Dec 1, 2000 • 1 min read

Circular Dichroism

Synergistic Use of Virtual Screening and Biophysical Methods for the Protein-Based Design of Peptidomimetics

Combining virtual screening with biophysical studies of protein-ligand complexes is an effective tool for designing new peptidomimetics.

Rognan, D.

• Nov 1, 2000 • 1 min read