The IMS Library: from IN-Stock to Virtual.
A chemical library is a key element in the early stages of pharmaceutical research.
A chemical library is a key element in the early stages of pharmaceutical research.
We previously reported Chalcone-4 (1) that binds the chemokine CXCL12, not its cognate receptors CXCR4 or CXCR7, and neutralizes its biological activity.
A rapid and atom economical multicomponent synthesis of complex aza-diketopiperazines (aza-DKPs) driven by Rh(I)-catalyzed hydroformylation of alkenylsemicarbazides is described.
G protein-coupled receptors (GPCRs) have been described to form hetero-oligomers.
Bitopic binding properties apply to a variety of muscarinic compounds that span and simultaneously bind to both the orthosteric and allosteric receptor sites.
A series of fluorescent benzazepine ligands for the arginine–vasopressin V2 receptor (AVP V2R) was synthesized using “Click” chemistry.
Two fluorescent derivatives of the M1 muscarinic selective agonist AC-42 were synthesized by coupling the lissamine rhodamine B fluorophore (in ortho and para positions) to …
The chemokine CXCL12 and the receptor CXCR4 play pivotal roles in normal vascular and neuronal development, in inflammatory responses, and in infectious diseases and cancer.