Haiech, J. | Chemogenomics Structural Group

Discovery of a Locally and Orally Active CXCL12 Neutraligand (LIT-927) with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia

We previously reported Chalcone-4 (1) that binds the chemokine CXCL12, not its cognate receptors CXCR4 or CXCR7, and neutralizes its biological activity.

Regenass, P.

• Sep 13, 2018 • 1 min read

Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD+ catabolizing enzyme

Schistosomiasis is a major tropical parasitic disease.

Kuhn, I.

• Nov 15, 2010 • 1 min read

Small Neutralizing Molecules to Inhibit Actions of the Chemokine CXCL12

The chemokine CXCL12 and the receptor CXCR4 play pivotal roles in normal vascular and neuronal development, in inflammatory responses, and in infectious diseases and cancer.

Hachet-Haas, M.

• Aug 22, 2008 • 1 min read