Two fluorescent derivatives of the M1 muscarinic selective agonist AC-42 were synthesized by coupling the lissamine rhodamine B fluorophore (in ortho and para positions) to …
Maraviroc is a nonpeptidic small molecule human immunodeficiency virus type 1 (HIV-1) entry inhibitor that has just entered the therapeutic arsenal for the treatment of patients.
Covering: up to the end of 2010 Natural products are made by nature through interaction with biosynthetic enzymes.
CD38 is a multifunctional enzyme which is ubiquitously distributed in mammalian tissues.
The sc-PDB database is an annotated archive of druggable binding sites extracted from the Protein Data Bank.
CC chemokine receptor 5 (CCR5) is a G-protein-coupled receptor for the chemokines CCL3, -4, and -5 and a coreceptor for entry of R5-tropic strains of human immunodeficiency virus …
Schistosomiasis is a major tropical parasitic disease.
The chemokine CXCL12 and the receptor CXCR4 play pivotal roles in normal vascular and neuronal development, in inflammatory responses, and in infectious diseases and cancer.
Structure-based virtual screening is a promising tool to identify putative targets for a specific ligand.
Quantification of local similarity between protein 3D structures is a promising tool in computer-aided drug design and prediction of biological function.