A simple and fuzzy method to align and compare druggable ligand-binding sites
A novel method to measure distances between druggable protein cavities is presented.
A novel method to measure distances between druggable protein cavities is presented.
A three-dimensional model of the chemokine receptor CCR5 has been built to fulfill structural peculiarities of its α-helix bundle and to distinguish known CCR5 antagonists from …
Schistosoma mansoni NAD(P)+ catabolizing enzyme (SmNACE) is a new member of the ADP-ribosyl cyclase family.
The sc-PDB is a collection of 6 415 three-dimensional structures of binding sites found in the Protein Data Bank (PDB).
The amino acid sequences of 369 human nonolfactory G-protein-coupled receptors (GPCRs) have been aligned at the seven transmembrane domain (TM) and used to extract the nature of 30 …
ADP-ribosyl cyclases are structurally conserved enzymes that are best known for catalyzing the production of the calcium-mobilizing metabolite, cyclic adenosine diphosphate ribose …
Zinc fingers are small structured protein domains that require the coordination of zinc for a stable tertiary fold.
The human general transcription factor TFIIH is involved in both transcription and DNA nucleotide excision repair.
The nucleocapsid protein (NCp7) of human immunodeficiency virus type 1 (HIV-1) contains two highly conserved CCHC zinc fingers that strongly bind Zn2+ through coordination of one …
The Protein Data Bank (PDB) has been processed to extract a screening protein library (sc-PDB) of 2148 entries.