Kuhn, I. | Chemogenomics Structural Group

Efficient Inhibition of SmNACE by Coordination Complexes Is Abolished by S. mansoni Sequestration of Metal

SmNACE is a NAD catabolizing enzyme expressed on the outer tegument of S.

Muller-Steffner, H.

• Jul 21, 2017 • 1 min read

Discovery of Potent Inhibitors of Schistosoma mansoni NAD+ Catabolizing Enzyme

The blood fluke Schistosoma mansoni is the causative agent of the intestinal form of schistosomiasis (or bilharzia).

Jacques, S. A.

• Apr 23, 2015 • 1 min read

Active Site

Probing the catalytic mechanism of bovine CD38/NAD+glycohydrolase by site directed mutagenesis of key active site residues

Bovine CD38/NAD+ glycohydrolase catalyzes the hydrolysis of NAD+ to nicotinamide and ADP-ribose and the formation of cyclic ADP-ribose via a stepwise reaction mechanism.

Kuhn, I.

• Jul 1, 2014 • 1 min read

CD38

Schistosoma mansoni NAD+ catabolizing enzyme: Identification of key residues in catalysis

Schistosoma mansoni NAD+ catabolizing enzyme (SmNACE), a distant homolog of mammalian CD38, shows significant structural and functional analogy to the members of the …

Kuhn, I.

• Dec 1, 2013 • 1 min read

Adenine

Insights into the Mechanism of Bovine CD38/NAD+Glycohydrolase from the X-Ray Structures of Its Michaelis Complex and Covalently-Trapped Intermediates

Bovine CD38/NAD+glycohydrolase (bCD38) catalyses the hydrolysis of NAD+ into nicotinamide and ADP-ribose and the formation of cyclic ADP-ribose (cADPR).

Egea, P. F.

• Apr 18, 2012 • 1 min read