Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival
NAD, a key co-enzyme required for cell metabolism, is synthesized via two pathways in most organisms.
NAD, a key co-enzyme required for cell metabolism, is synthesized via two pathways in most organisms.
SmNACE is a NAD catabolizing enzyme expressed on the outer tegument of S.
The blood fluke Schistosoma mansoni is the causative agent of the intestinal form of schistosomiasis (or bilharzia).
Schistosoma mansoni NAD(P)+ catabolizing enzyme (SmNACE) is a new member of the ADP-ribosyl cyclase family.
ADP-ribosyl cyclases are structurally conserved enzymes that are best known for catalyzing the production of the calcium-mobilizing metabolite, cyclic adenosine diphosphate ribose …