Structural analysis of neomycin B and kanamycin A binding Aminoglycosides Modifying Enzymes (AME) and bacterial ribosomal RNA.
Aminoglycosides are crucial antibiotics facing challenges from bacterial resistance.
Aminoglycosides are crucial antibiotics facing challenges from bacterial resistance.
The fragment approach has emerged as a method of choice for drug design, as it allows difficult therapeutic targets to be addressed.
Screening of fragment libraries is a valuable approach to the drug discovery process.