sc-PDB: a 3D-database of ligandable binding sites—10 years on
The sc-PDB database (available at http://bioinfo-pharma.
The sc-PDB database (available at http://bioinfo-pharma.
Background and Purpose The transmembrane protein LINGO-1 is a negative regulator in the nervous system mainly affecting axonal regeneration, neuronal survival, oligodendrocyte …
Training machine learning algorithms with protein–ligand descriptors has recently gained considerable attention to predict binding constants from atomic coordinates.
Abstract This work describes a collaborative effort to define and apply a protocol for the rational selection of a general-purpose screening library, to be used by the screening …
Bioisosteric replacement plays an important role in medicinal chemistry by keeping the biological activity of a molecule while changing either its core scaffold or substituents, …
The Smoothened (Smo) receptor is a key transducer of the Hedgehog (Hh) signaling pathway, which plays a critical role in tissue maintenance and repair.
Pyochelin is a siderophore common to all strains of Pseudomonas aeruginosa utilized by this Gram-negative bacterium to acquire iron(III).
Tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4) is frequently overexpressed in carcinomas, suggesting a specific role in cancer.
Le récepteur Smoothened (Smo) joue un rôle essentiel dans la transduction de la voie de signalisation Hedgehog (Hh) chez les vertébrés au cours de l’embryogenèse et chez l’adulte.