Schuber, F. | Chemogenomics Structural Group

Discovery of Potent Inhibitors of Schistosoma mansoni NAD+ Catabolizing Enzyme

The blood fluke Schistosoma mansoni is the causative agent of the intestinal form of schistosomiasis (or bilharzia).

Jacques, S. A.

• Apr 23, 2015 • 1 min read

Probing the catalytic mechanism of bovine CD38/NAD+glycohydrolase by site directed mutagenesis of key active site residues

Bovine CD38/NAD+ glycohydrolase catalyzes the hydrolysis of NAD+ to nicotinamide and ADP-ribose and the formation of cyclic ADP-ribose via a stepwise reaction mechanism.

Kuhn, I.

• Jul 1, 2014 • 1 min read

CD38

Schistosoma mansoni NAD+ catabolizing enzyme: Identification of key residues in catalysis

Schistosoma mansoni NAD+ catabolizing enzyme (SmNACE), a distant homolog of mammalian CD38, shows significant structural and functional analogy to the members of the …

Kuhn, I.

• Dec 1, 2013 • 1 min read

Adenine

Insights into the Mechanism of Bovine CD38/NAD+Glycohydrolase from the X-Ray Structures of Its Michaelis Complex and Covalently-Trapped Intermediates

Bovine CD38/NAD+glycohydrolase (bCD38) catalyses the hydrolysis of NAD+ into nicotinamide and ADP-ribose and the formation of cyclic ADP-ribose (cADPR).

Egea, P. F.

• Apr 18, 2012 • 1 min read

Anthocyanidins

Flavonoids as inhibitors of human CD38

CD38 is a multifunctional enzyme which is ubiquitously distributed in mammalian tissues.

Kellenberger, E.

• Jul 1, 2011 • 1 min read

Anthocyanidins

Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD+ catabolizing enzyme

Schistosomiasis is a major tropical parasitic disease.

Kuhn, I.

• Nov 15, 2010 • 1 min read

Redesign of Schistosoma mansoni NAD+ Catabolizing Enzyme: Active Site H103W Mutation Restores ADP-Ribosyl Cyclase Activity

Schistosoma mansoni NAD(P)+ catabolizing enzyme (SmNACE) is a new member of the ADP-ribosyl cyclase family.

Kuhn, I.

• Oct 1, 2006 • 1 min read

Production of Calcium-Mobilizing Metabolites by a Novel Member of the ADP-Ribosyl Cyclase Family Expressed in Schistosoma mansoni,

ADP-ribosyl cyclases are structurally conserved enzymes that are best known for catalyzing the production of the calcium-mobilizing metabolite, cyclic adenosine diphosphate ribose …

Goodrich, S. P.

• Aug 1, 2005 • 1 min read