Sturm, N. | Chemogenomics Structural Group

Structural Searching of Biosynthetic Enzymes to Predict Protein Targets of Natural Products

Recently, we have demonstrated that site comparison methodology using flavonoid biosynthetic enzymes as the query could automatically identify structural features common to …

Sturm, N.

• Mar 1, 2018 • 1 min read

Comparing atom-based with residue-based descriptors in predicting binding site similarity: do backbone atoms matter?

Aim: We question the level of detail required in protein 3D-representation to detect site similarity which is relevant for polypharmacology prediction.

Sturm, N.

• Sep 15, 2016 • 1 min read

Key Words

Similarity between Flavonoid Biosynthetic Enzymes and Flavonoid Protein Targets Captured by Three-Dimensional Computing Approach

Natural products are made by nature through interaction with biosynthetic enzymes.

Sturm, N.

• Apr 1, 2015 • 1 min read

Structural Insights into the Molecular Basis of the Ligand Promiscuity

Selectivity is a key factor in drug development.

Sturm, N.

• Sep 24, 2012 • 1 min read