Trinquet, E. | Chemogenomics Structural Group

Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice

Peripheral neuropathic pain (PNP) is a debilitating and intractable chronic disease, for which sensitization of somatosensory neurons present in dorsal root ganglia that project to …

Rivat, C.

• Mar 12, 2018 • 1 min read

Time-Resolved FRET Binding Assay to Investigate Hetero-Oligomer Binding Properties: Proof of Concept with Dopamine D1/D3 Heterodimer

G protein-coupled receptors (GPCRs) have been described to form hetero-oligomers.

Hounsou, C.

• Feb 20, 2015 • 1 min read

Selective Fluorescent Nonpeptidic Antagonists For Vasopressin V2 GPCR: Application To Ligand Screening and Oligomerization Assays.

A series of fluorescent benzazepine ligands for the arginine–vasopressin V2 receptor (AVP V2R) was synthesized using “Click” chemistry.

Loison, S.

• Oct 25, 2012 • 1 min read