From the three-dimensional structure of the class I major histocompatibility complex (MHC) HLA-B*2705 protein, several nonnatural peptides were designed either to optimize the …
Truncated protein-ligand active-site complexes were studied by molecular dynamics simulations.
The class I major histocompatibility complex-encoded HLA-B*2705 protein was simulated in complex with six different peptides exhibiting unexpected structure-activity relationships.
The recently described potent and selective GABAA antagonist SR 95531 (gabazine) is compared to six other GABAA antagonists: (+)-bicuculline, (-)-securinine, (+)-tubocurarine, …
Nicht α-helical, sondern gestreckt ist die Konformation des antigenen Peptids in der Bindungstasche des menschlichen Haupt-Histokompatibilitätskomplex-(MHC)-Proteins HLA-A2 der …
The conformation is not α-helical, but extended when the antigenic peptide binds in the pocket of the human major histocompatibility complex (MHC) protein HLA-A2 of class I.
Computer simulation of the conformations of short antigenic peptides (5–10 residues) either free or bound to their receptor, the major histocompatibility complex (MHC)-encoded …
The structure of the influenza-virus-matrix-protein (IMP) 58-66 nonapeptide, bound to the major-histocompatibility-complex-encoded human leukocyte antigen (HLA) A2 protein was …
Substituent variations on the pyrrolidinyl nitrogen of sulpiride, a selective D2 dopamine antagonist, showed that in vitro and in vivo activities are concentrated in the (S) …