Targeting of specific CCR5-G protein complexes underlies biased signaling by HIV-1 envelope glycoproteins.

CCR5 is a critical receptor for anti-infectious immunity. It acts by binding chemokines, which activate Gαβγ protein-dependent signaling and ultimately regulate leukocyte recruitment. However, CCR5 is also implicated in numerous pathological conditions, raising interest in its potential as a therapeutic target. Notably, CCR5 serves as a coreceptor for HIV-1 envelope glycoproteins (Envs), allowing viral entry into host cells and initiating infection. Whether and how Envs trigger CCR5 signaling remains debated, with conflicting evidence regarding their ability to mimic chemokine-induced activation of the receptor. This study aims to clarify the nature of Env-induced CCR5 signaling.

Journal article

Targeting of specific CCR5-G protein complexes underlies biased signaling by HIV-1 envelope glycoproteins., Cell Commun Signal 23, 505 (2025).