Allosteric Modulators

Structure-Based Discovery of Allosteric Modulators of Two Related Class B G-Protein-Coupled Receptors

Abstract Despite the availability of X-ray crystal structure data for several members of the G-protein-coupled receptor (GPCR) superfamily, structure-based discovery of GPCR …

De Graaf, C.

Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor

GPRC6A displays high sequence homology to the Ca2+-sensing receptor (CaSR).

Faure, H.