Binding Mode

Framycetin/Chemistry/Pharmacology

Structural analysis of neomycin B and kanamycin A binding Aminoglycosides Modifying Enzymes (AME) and bacterial ribosomal RNA.

Aminoglycosides are crucial antibiotics facing challenges from bacterial resistance.

Revillo Imbernon, J.

• Jul 1, 2024 • 1 min read

Mining the Protein Data Bank to inspire fragment library design.

The fragment approach has emerged as a method of choice for drug design, as it allows difficult therapeutic targets to be addressed.

Revillo Imbernon, J.

• Jan 1, 2023 • 1 min read

Modeling of CCR5 Recognition by HIV-1 gp120: How the Viral Protein Exploits the Conformational Plasticity of the Coreceptor.

The chemokine receptor CCR5 is a key player in HIV-1 infection.

Jacquemard, C.

• Jul 18, 2021 • 1 min read