Structure-Based Detection of Orthosteric and Allosteric Pockets at Protein-Protein Interfaces
Protein-protein interfaces represent challenging but very promising targets to discover novel drugs with exquisite specificity profiles.
Protein-protein interfaces represent challenging but very promising targets to discover novel drugs with exquisite specificity profiles.
The Phe(3) residue of the N-terminal tetrapeptide of dermorphin (H-Dmt-d-Ala-Phe-Gly-NH(2)) was conformationally constrained using 4- or 5-methyl-substituted …
This review will focus on the construction, refinement, and validation of G Protein-coupled receptor models for the purpose of structure-based virtual screening.
We have recently proposed a macromolecular prodrug strategy for improved cancer chemotherapy based on two features (Kratz, F.
A new computational method (EpiDock) is proposed for predicting peptide binding to class I MHC proteins, from the amino acid sequence of any protein of immunological interest.
Oligopeptides that interact with oxoanions were developed by rational design methods.
We describe here fluorescence polarization-based methods to investigate class I MHC-peptide interactions in solution.
Starting from the X-ray structure of a class I major histocompatibility complex (MHC)-encoded protein (HLA-B*2705), a naturally presented self-nonapeptide and two synthetic …