Mining the Protein Data Bank to inspire fragment library design.
The fragment approach has emerged as a method of choice for drug design, as it allows difficult therapeutic targets to be addressed.
The fragment approach has emerged as a method of choice for drug design, as it allows difficult therapeutic targets to be addressed.
Rationalizing the identification of hidden similarities across the repertoire of druggable protein cavities remains a major hurdle to a true proteome-wide structure-based …
A novel method to measure distances between druggable protein cavities is presented.