X-Ray Diffraction

Mutation of cis-proline 207 in mitochondrial creatine kinase to alanine leads to increased acid stability.

We show that the mutation of an uncharged residue far from the active site to another uncharged residue can have effects on the active site without disturbing the overall structure …

Forstner, M.

• Jul 1, 1998 • 1 min read

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Structure and molecular modeling of GABA-A receptor antagonists.

The recently described potent and selective GABAA antagonist SR 95531 (gabazine) is compared to six other GABAA antagonists: (+)-bicuculline, (-)-securinine, (+)-tubocurarine, …

Rognan, D.

• May 1, 1992 • 1 min read